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  1. Research

    LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

    The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goat...

    Ø. Salvesen, M. R. Reiten, A. Espenes, M. K. Bakkebø, M. A. Tranulis and C. Ersdal

    Journal of Neuroinflammation 2017 14:106

    Published on: 22 May 2017

  2. Research

    Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

    The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the...

    Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij and Esther Lutgens

    Journal of Neuroinflammation 2017 14:105

    Published on: 12 May 2017

  3. Research

    Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage

    Early brain injury (EBI) is considered a major contributor to the high morbidity and mortality associated with subarachnoid haemorrhage (SAH). Both of sterile inflammation and apoptosis are considered the impo...

    Qing Zhao, Xudong Che, Hongxia Zhang, Pianpian Fan, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Yidan Liang, Xiaochuan Sun and Zhaohui He

    Journal of Neuroinflammation 2017 14:104

    Published on: 11 May 2017

  4. Short report

    A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

    Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenti...

    Euan R. O. Allan, Rhiannon I. Campden, Benjamin W. Ewanchuk, Pankaj Tailor, Dale R. Balce, Neil T. McKenna, Catherine J. Greene, Amy L. Warren, Thomas Reinheckel and Robin M. Yates

    Journal of Neuroinflammation 2017 14:103

    Published on: 10 May 2017

  5. Research

    Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

    In recent years, proinflammatory cytokine interleukin-1β (IL-1β) was considered to play a critical role in the pathogenesis of depression. In addition, P2X7 receptor (P2X7R), a member of the purinergic recepto...

    Na Yue, Huijie Huang, Xiaocang Zhu, Qiuqin Han, Yalin Wang, Bing Li, Qiong Liu, Gencheng Wu, Yuqiu Zhang and Jin Yu

    Journal of Neuroinflammation 2017 14:102

    Published on: 10 May 2017

  6. Research

    Sex-dependent treatment of chronic EAE with partial MHC class II constructs

    One of the main challenges in treating multiple sclerosis (MS) is reversing the effects of accumulated damage in the central nervous system (CNS) of progressive MS subjects. While most of the available drugs f...

    Gil Benedek, Priya Chaudhary, Roberto Meza-Romero, Evan Calkins, Gail Kent, Halina Offner, Dennis Bourdette and Arthur A. Vandenbark

    Journal of Neuroinflammation 2017 14:100

    Published on: 6 May 2017

  7. Research

    Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

    As the primary immune response cell in the central nervous system, microglia constantly monitor the microenvironment and respond rapidly to stress, infection, and injury, making them important modulators of ne...

    Kelly S. Kirkley, Katriana A. Popichak, Maryam F. Afzali, Marie E. Legare and Ronald B. Tjalkens

    Journal of Neuroinflammation 2017 14:99

    Published on: 5 May 2017

  8. Research

    HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury

    Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo. However, underlying mec...

    Jun-peng Pei, Li-hong Fan, Kai Nan, Jia Li, Xiao-qian Dang and Kun-zheng Wang

    Journal of Neuroinflammation 2017 14:97

    Published on: 3 May 2017

  9. Research

    Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice

    Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant efficacy of kososan and potential mechanisms are la...

    Naoki Ito, Eiji Hirose, Tatsuya Ishida, Atsushi Hori, Takayuki Nagai, Yoshinori Kobayashi, Hiroaki Kiyohara, Tetsuro Oikawa, Toshihiko Hanawa and Hiroshi Odaguchi

    Journal of Neuroinflammation 2017 14:98

    Published on: 3 May 2017

  10. Research

    YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

    Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened...

    Zheng-Yi Li, Yoon Hee Chung, Eun-Joo Shin, Duy-Khanh Dang, Ji Hoon Jeong, Sung Kwon Ko, Seung-Yeol Nah, Tae Gon Baik, Jin Hyeong Jhoo, Wei-Yi Ong, Toshitaka Nabeshima and Hyoung-Chun Kim

    Journal of Neuroinflammation 2017 14:94

    Published on: 27 April 2017

  11. Research

    Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

    The consumption of large amounts of dietary fats is one of the most important environmental factors contributing to the development of obesity and metabolic disorders. GPR120 and GPR40 are polyunsaturated fatt...

    Nathalia R. V. Dragano, Carina Solon, Albina F. Ramalho, Rodrigo F. de Moura, Daniela S. Razolli, Elisabeth Christiansen, Carlos Azevedo, Trond Ulven and Licio A. Velloso

    Journal of Neuroinflammation 2017 14:91

    Published on: 26 April 2017

  12. Research

    Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection

    Fingolimod, a sphingosine-1-phosphate receptor modulator with well-described immunomodulatory properties involving peripheral immune cell trafficking, was the first oral agent approved for the treatment of rel...

    Björn Ambrosius, Kalliopi Pitarokoili, Lisa Schrewe, Xiomara Pedreiturria, Jeremias Motte and Ralf Gold

    Journal of Neuroinflammation 2017 14:92

    Published on: 26 April 2017

  13. Research

    GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma

    We previously reported a profound long-term neuroprotection subsequent to a single radiation-therapy in the DBA/2J mouse model of glaucoma. This neuroprotection prevents entry of monocyte-like immune cells int...

    Pete A. Williams, Catherine E. Braine, Nicole E. Foxworth, Kelly E. Cochran and Simon W. M. John

    Journal of Neuroinflammation 2017 14:93

    Published on: 26 April 2017

  14. Research

    Exercise attenuates neurological deficits by stimulating a critical HSP70/NF-κB/IL-6/synapsin I axis in traumatic brain injury rats

    Despite previous evidence for a potent inflammatory response after a traumatic brain injury (TBI), it is unknown whether exercise preconditioning (EP) improves outcomes after a TBI by modulating inflammatory r...

    Chung-Ching Chio, Hung-Jung Lin, Yu-Feng Tian, Yu-Chieh Chen, Mao-Tsun Lin, Cheng-Hsien Lin, Ching-Ping Chang and Chien-Chin Hsu

    Journal of Neuroinflammation 2017 14:90

    Published on: 24 April 2017

  15. Research

    Early strong intrathecal inflammation in cerebellar type multiple system atrophy by cerebrospinal fluid cytokine/chemokine profiles: a case control study

    The pathology of multiple system atrophy cerebellar-type (MSA-C) includes glial inflammation; however, cerebrospinal fluid (CSF) inflammatory cytokine profiles have not been investigated. In this study, we det...

    Ryo Yamasaki, Hiroo Yamaguchi, Takuya Matsushita, Takayuki Fujii, Akio Hiwatashi and Jun-ichi Kira

    Journal of Neuroinflammation 2017 14:89

    Published on: 24 April 2017

  16. Research

    Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress

    The majority of Parkinson’s disease (PD) cases are sporadic and idiopathic suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors. Stress and neuroinflammation ...

    Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M. Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher and Bruno Conti

    Journal of Neuroinflammation 2017 14:88

    Published on: 21 April 2017

  17. Research

    Adiponectin levels in the serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients: possible influence on neuroinflammation?

    Adiponectin (APN) is a key player in energy homeostasis strictly associated with cerebrovascular and neurodegenerative diseases. Since APN also belongs to anti-inflammatory-acting adipokines and may influence ...

    Patrizia Bossolasco, Raffaella Cancello, Alberto Doretti, Claudia Morelli, Vincenzo Silani and Lidia Cova

    Journal of Neuroinflammation 2017 14:85

    Published on: 20 April 2017

  18. Research

    TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase

    Extracellular vesicles (EVs) are membrane-contained vesicles shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication. The release of EVs...

    Kaizhe Wang, Ling Ye, Hongfang Lu, Huili Chen, Yanyan Zhang, Yunlong Huang and Jialin C. Zheng

    Journal of Neuroinflammation 2017 14:87

    Published on: 20 April 2017

  19. Research

    Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

    Exposure to traffic-related air pollution (TRAP) is associated with accelerated cognitive aging and higher dementia risk in human populations. Rodent brains respond to TRAP with activation of astrocytes and mi...

    Nicholas C. Woodward, Morgan C. Levine, Amin Haghani, Farimah Shirmohammadi, Arian Saffari, Constantinos Sioutas, Todd E. Morgan and Caleb E. Finch

    Journal of Neuroinflammation 2017 14:84

    Published on: 14 April 2017

  20. Research

    Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

    Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role...

    Pallavi Shrivastava, Miguel A. Cabrera, Lucy G. Chastain, Nadka I. Boyadjieva, Shaima Jabbar, Tina Franklin and Dipak K. Sarkar

    Journal of Neuroinflammation 2017 14:83

    Published on: 14 April 2017

  21. Research

    The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis

    Previous work from our laboratory has demonstrated that during acute viral brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD-L1 pathway, thereby limiting the delete...

    Sujata Prasad, Shuxian Hu, Wen S. Sheng, Priyanka Chauhan, Amar Singh and James R. Lokensgard

    Journal of Neuroinflammation 2017 14:82

    Published on: 13 April 2017

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