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  1. Research

    Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity

    Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) and other progressive neurodegenerative d...

    Wei-Xing Zhao, Jun-Han Zhang, Jiang-Bei Cao, Wei Wang, Dong-Xin Wang, Xiao-Ying Zhang, Jun Yu, Yong-Yi Zhang, You-Zhi Zhang and Wei-Dong Mi

    Journal of Neuroinflammation 2017 14:17

    Published on: 21 January 2017

  2. Research

    Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration

    The bromodomain and extraterminal domain (BET) family proteins (BET2, BET3, and BET4) “read” (bind) histone acetylation marks via two distinct bromodomains (Brom1 and Brom2) facilitating transcriptional activa...

    Lei Zhao, Jun Li, Yingmei Fu, Mengxue Zhang, Bowen Wang, Jonathan Ouellette, Pawan K. Shahi, Bikash R. Pattnaik, Jyoti J. Watters, Wai T. Wong and Lian-Wang Guo

    Journal of Neuroinflammation 2017 14:14

    Published on: 19 January 2017

  3. Research

    Activation of human B cells negatively regulates TGF-β1 production

    Accumulating evidence indicate that B cells can exhibit pro- or anti-inflammatory activities. Similar to interleukin (IL)-10–competent B cells, we recently showed that transforming growth factor (TGF)-β1-produ...

    Nicolas Molnarfi, Kristbjörg Bjarnadóttir, Mahdia Benkhoucha, Catherine Juillard and Patrice H. Lalive

    Journal of Neuroinflammation 2017 14:13

    Published on: 19 January 2017

  4. Research

    Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

    Inflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 bet...

    Chi-Wei Huang, Shih-Wei Hsu, Shih-Jen Tsai, Nai-Ching Chen, Mu-En Liu, Chen-Chang Lee, Shu-Hua Huang, Weng-Neng Chang, Ya-Ting Chang, Wan-Chen Tsai and Chiung-Chih Chang

    Journal of Neuroinflammation 2017 14:12

    Published on: 18 January 2017

  5. Research

    BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

    B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recr...

    M. Puthenparampil, L. Federle, S. Miante, A. Zito, E. Toffanin, S. Ruggero, M. Ermani, S. Pravato, D. Poggiali, P. Perini, F. Rinaldi and P. Gallo

    Journal of Neuroinflammation 2017 14:11

    Published on: 17 January 2017

  6. Review

    Inflammation in epileptogenesis after traumatic brain injury

    Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizures contribute to progressive neurodegeneration and poor functional and psychosocial outcomes for TBI survivors, and epil...

    Kyria M. Webster, Mujun Sun, Peter Crack, Terence J. O’Brien, Sandy R. Shultz and Bridgette D. Semple

    Journal of Neuroinflammation 2017 14:10

    Published on: 13 January 2017

  7. Research

    Absence of system xc on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

    Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability. Accumulating evidence points to a key role for...

    Ellen Merckx, Giulia Albertini, Magdalena Paterka, Cathy Jensen, Philipp Albrecht, Michael Dietrich, Joeri Van Liefferinge, Eduard Bentea, Lise Verbruggen, Thomas Demuyser, Lauren Deneyer, Jan Lewerenz, Geert van Loo, Jacques De Keyser, Hideyo Sato, Pamela Maher…

    Journal of Neuroinflammation 2017 14:9

    Published on: 13 January 2017

  8. Research

    Microglial activation in Parkinson’s disease using [18F]-FEPPA

    Neuroinflammatory processes including activated microglia have been reported to play an important role in Parkinson’s disease (PD). Increased expression of translocator protein (TSPO) has been observed after b...

    Christine Ghadery, Yuko Koshimori, Sarah Coakeley, Madeleine Harris, Pablo Rusjan, Jinhee Kim, Sylvain Houle and Antonio P. Strafella

    Journal of Neuroinflammation 2017 14:8

    Published on: 11 January 2017

  9. Research

    WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism

    α/β-Hydrolase domain 6 (ABHD6) is one of the major enzymes for endocannabinoid 2-arachidonoylglycerol (2-AG) hydrolysis in microglia cells. Our recent studies have shown that a selective ABHD6 inhibitor WWL70 ...

    Mikiei Tanaka, Sean Moran, Jie Wen, Kwame Affram, Tinghua Chen, Aviva J. Symes and Yumin Zhang

    Journal of Neuroinflammation 2017 14:7

    Published on: 10 January 2017

  10. Research

    Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

    Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life...

    Yangzi Zhu, Yu Wang, Rui Yao, Ting Hao, Junli Cao, He Huang, Liwei Wang and Yuqing Wu

    Journal of Neuroinflammation 2017 14:6

    Published on: 7 January 2017

  11. Research

    Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide

    Cyclooxygenase-2 (COX-2) is induced under inflammatory conditions, and prostaglandin E2 (PGE2) is one of the products of COX activity. PGE2 has pleiotropic actions depending on the activation of specific E-type p...

    Ester Bonfill-Teixidor, Amaia Otxoa-de-Amezaga, Miriam Font-Nieves, M. Glòria Sans-Fons and Anna M. Planas

    Journal of Neuroinflammation 2017 14:3

    Published on: 5 January 2017

  12. Research

    Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator

    Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443...

    Sven Micklisch, Yuchen Lin, Saskia Jacob, Marcus Karlstetter, Katharina Dannhausen, Prasad Dasari, Monika von der Heide, Hans-Martin Dahse, Lisa Schmölz, Felix Grassmann, Medhanie Alene, Sascha Fauser, Harald Neumann, Stefan Lorkowski, Diana Pauly, Bernhard H. Weber…

    Journal of Neuroinflammation 2017 14:4

    Published on: 5 January 2017

  13. Research

    Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity

    Diet-induced hypothalamic inflammation is an important mechanism leading to dysfunction of neurons involved in controlling body mass. Studies have shown that polyunsaturated fats can reduce hypothalamic inflam...

    Livia B. Pascoal, Bruna Bombassaro, Albina F. Ramalho, Andressa Coope, Rodrigo F. Moura, Felipe Correa-da-Silva, Leticia Ignacio-Souza, Daniela Razolli, Diogo de Oliveira, Rodrigo Catharino and Licio A. Velloso

    Journal of Neuroinflammation 2017 14:5

    Published on: 5 January 2017

  14. Research

    Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

    Treatment of mild-moderate Alzheimer’s disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and act...

    Charbel Moussa, Michaeline Hebron, Xu Huang, Jaeil Ahn, Robert A. Rissman, Paul S. Aisen and R. Scott Turner

    Journal of Neuroinflammation 2017 14:1

    Published on: 3 January 2017

  15. Research

    Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

    Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related t...

    E. Soemirien Kasanmoentalib, Mercedes Valls Seron, Bart Ferwerda, Michael W. Tanck, Aeilko H. Zwinderman, Frank Baas, Arie van der Ende, Matthijs C. Brouwer and Diederik van de Beek

    Journal of Neuroinflammation 2017 14:2

    Published on: 3 January 2017

  16. Research

    Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains

    Infectious encephalitides are most often associated with acute seizures during the infection period and are risk factors for the development of epilepsy at later times. Mechanisms of viral encephalitis-induced...

    Nina Dupuis, Andrey Mazarati, Béatrice Desnous, Vibol Chhor, Bobbi Fleiss, Tifenn Le Charpentier, Sophie Lebon, Zsolt Csaba, Pierre Gressens, Pascal Dournaud and Stéphane Auvin

    Journal of Neuroinflammation 2016 13:307

    Published on: 12 December 2016

  17. Research

    Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

    Understanding blood-brain barrier responses to inflammatory stimulation (such as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that could be the result of local or systemic inflammat...

    Jacquelyn A. Brown, Simona G. Codreanu, Mingjian Shi, Stacy D. Sherrod, Dmitry A. Markov, M. Diana Neely, Clayton M. Britt, Orlando S. Hoilett, Ronald S. Reiserer, Philip C. Samson, Lisa J. McCawley, Donna J. Webb, Aaron B. Bowman, John A. McLean and John P. Wikswo

    Journal of Neuroinflammation 2016 13:306

    Published on: 12 December 2016

  18. Research

    miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling

    Hyperglycemia is a significant risk factor for diabetic retinopathy and induces increased inflammatory responses and retinal leukostasis, as well as vascular damage. Although there is an increasing amount of e...

    Eun-Ah Ye, Li Liu, Youde Jiang, Jenny Jan, Subhash Gaddipati, Susmit Suvas and Jena J. Steinle

    Journal of Neuroinflammation 2016 13:305

    Published on: 8 December 2016

  19. Research

    LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

    Neuroinflammation is characterized by microglial activation and the increased levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence has implicated both beneficial and toxic ro...

    Longyu Yang, Chia-Chen Liu, Honghua Zheng, Takahisa Kanekiyo, Yuka Atagi, Lin Jia, Daxin Wang, Aurelie N’songo, Dan Can, Huaxi Xu, Xiao-Fen Chen and Guojun Bu

    Journal of Neuroinflammation 2016 13:304

    Published on: 8 December 2016

  20. Research

    Tollip, an early regulator of the acute inflammatory response in the substantia nigra

    Tollip is a ubiquitously expressed protein, originally described as a modulator of the IL-1R/TLR-NF-κB signaling pathways. Although this property has been well characterized in peripheral cells, and despite so...

    Marie Humbert-Claude, D. Duc, D. Dwir, L. Thieren, J. Sandström von Tobel, C. Begka, F. Legueux, D. Velin, M. H. Maillard, K. Q. Do, F. Monnet-Tschudi and L. Tenenbaum

    Journal of Neuroinflammation 2016 13:303

    Published on: 7 December 2016

  21. Research

    Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα

    Multiple sclerosis (MS) is a chronic CNS autoimmune disease characterized by inflammation, demyelination, and neuronal degeneration, where myelin-specific CD4 T cells play critical roles in the formation of ac...

    Patrick K Nuro-Gyina, Elizabeth L Rieser, Marissa C Granitto, Wei Pei, Yue Liu, Priscilla W Lee, Saba Aqel, Jian Zhang, Amy E Lovett-Racke, Michael K Racke and Yuhong Yang

    Journal of Neuroinflammation 2016 13:302

    Published on: 3 December 2016

  22. Research

    Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury

    Traumatic brain injury (TBI) patients in military settings can be exposed to prolonged periods of hypobaria (HB) during aeromedical evacuation. Hypobaric exposure, even with supplemental oxygen to prevent hypo...

    Jacob W. Skovira, Junfang Wu, Jessica J. Matyas, Alok Kumar, Marie Hanscom, Shruti V. Kabadi, Raymond Fang and Alan I. Faden

    Journal of Neuroinflammation 2016 13:299

    Published on: 1 December 2016

  23. Research

    Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

    Studies of neuromyelitis optica (NMO), an autoimmune disease of the central nervous system (CNS), have demonstrated that autoantibodies against the water channel aquaporin-4 (AQP4) induce astrocyte damage thro...

    Yiting Liu, Danielle E. Harlow, Katherine S. Given, Gregory P. Owens, Wendy B. Macklin and Jeffrey L. Bennett

    Journal of Neuroinflammation 2016 13:301

    Published on: 1 December 2016

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