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  1. Research

    Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

    This study was designed to explore the beneficial effects of environmental enrichment (EE) on white matter glial changes in a mouse model of chronic cerebral hypoperfusion induced by bilateral common carotid a...

    Yoshiki Hase, Lucinda Craggs, Mai Hase, William Stevenson, Janet Slade, Dianne Lopez, Rubin Mehta, Aiqing Chen, Di Liang, Arthur Oakley, Masafumi Ihara, Karen Horsburgh and Raj N. Kalaria

    Journal of Neuroinflammation 2017 14:81

    Published on: 11 April 2017

  2. Research

    The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis

    The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory ...

    Ludmila T. Nogueira, Deiziane V. S. Costa, Antoniella S. Gomes, Conceição S. Martins, Angeline M. H. P. Silva, Juliana M. Coelho-Aguiar, Patrícia Castelucci, Roberto C. P. Lima-Júnior, Renata F. C. Leitão, Vivaldo Moura-Neto and Gerly A. C. Brito

    Journal of Neuroinflammation 2017 14:79

    Published on: 7 April 2017

  3. Research

    Diffusion MRI quantifies early axonal loss in the presence of nerve swelling

    Magnetic resonance imaging markers have been widely used to detect and quantify white matter pathologies in multiple sclerosis. We have recently developed a diffusion basis spectrum imaging (DBSI) to distingui...

    Tsen-Hsuan Lin, Chia-Wen Chiang, Carlos J. Perez-Torres, Peng Sun, Michael Wallendorf, Robert E. Schmidt, Anne H. Cross and Sheng-Kwei Song

    Journal of Neuroinflammation 2017 14:78

    Published on: 7 April 2017

  4. Research

    Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring

    Birth cohort studies link gestational diabetes mellitus (GDM) with impaired cognitive performance in the offspring. However, the mechanisms involved are unknown. We tested the hypothesis that obesity-associate...

    Billy Vuong, Gary Odero, Stephanie Rozbacher, Mackenzie Stevenson, Stephanie M. Kereliuk, Troy J. Pereira, Vernon W. Dolinsky and Tiina M. Kauppinen

    Journal of Neuroinflammation 2017 14:80

    Published on: 7 April 2017

  5. Erratum

    Erratum to: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis

    E. Soemirien Kasanmoentalib, Mercedes Valls Seron, Bart Ferwerda, Michael W. Tanck, Aeilko H. Zwinderman, Frank Baas, Arie van der Ende, William J. Schwaeble, Matthijs C. Brouwer and Diederik van de Beek

    Journal of Neuroinflammation 2017 14:77

    Published on: 6 April 2017

    The original article was published in Journal of Neuroinflammation 2017 14:2

  6. Research

    Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

    Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an ...

    Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Späni, Saktimayee M. Roy, D. Martin Watterson and Linda J. Van Eldik

    Journal of Neuroinflammation 2017 14:75

    Published on: 5 April 2017

  7. Research

    Microglia activation is essential for BMP7-mediated retinal reactive gliosis

    Our previous studies have shown that BMP7 is able to trigger activation of retinal macroglia. However, these studies showed the responsiveness of Müller glial cells and retinal astrocytes in vitro was attenuat...

    Subramanian Dharmarajan, Debra L. Fisk, Christine M. Sorenson, Nader Sheibani and Teri L. Belecky-Adams

    Journal of Neuroinflammation 2017 14:76

    Published on: 5 April 2017

  8. Research

    Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression

    Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU)...

    Hai-Jiao Liu, Xiu-Xiu Pan, Bing-Qian Liu, Xuan Gui, Liang Hu, Chun-Yi Jiang, Yuan Han, Yi-Xin Fan, Yu-Lin Tang and Wen-Tao Liu

    Journal of Neuroinflammation 2017 14:74

    Published on: 4 April 2017

  9. Case report

    Atypical periodic alternating nystagmus responding to high-dose intravenous immunoglobulins: a case report

    Acquired periodic alternating nystagmus (PAN) is a rare but well-defined syndrome that consists of a horizontal nystagmus that cyclically reverses its direction. PAN can be caused by degenerative, neoplastic, ...

    Herminia Argente-Escrig, Luis Bataller, Claudio Krstulovic Roa, Vanesa Pérez Guillén, Herminio Perez Garrigues and Bonaventura Casanova Estruch

    Journal of Neuroinflammation 2017 14:71

    Published on: 31 March 2017

  10. Research

    Cytokine cascades induced by mechanical trauma injury alter voltage-gated sodium channel activity in intact cortical neurons

    Traumatic brain injury (TBI) triggers both immediate (primary) and long-term (secondary) tissue damages. Secondary damages can last from hours to days or even a lifetime. Secondary damages implicate several me...

    Weiqiang Chen, Jiangtao Sheng, Jingfang Guo, Guoyi Peng, Jinfang Hong, Bingbing Li, Xiaoxuan Chen, Kangsheng Li and Shousen Wang

    Journal of Neuroinflammation 2017 14:73

    Published on: 31 March 2017

  11. Research

    Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment

    Mitochondria are abundant organelles critical for energy metabolism and brain function. Mitochondrial DNA (mtDNA), released during cellular injury and as part of the innate immune response to viral pathogens, ...

    Sanjay R. Mehta, Josué Pérez-Santiago, Todd Hulgan, Tyler R. C. Day, Jill Barnholtz-Sloan, Haley Gittleman, Scott Letendre, Ronald Ellis, Robert Heaton, Stephanie Patton, Jesse D. Suben, Donald Franklin, Debralee Rosario, David B. Clifford, Ann C. Collier, Christina M. Marra…

    Journal of Neuroinflammation 2017 14:72

    Published on: 31 March 2017

  12. Research

    Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat

    MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways ...

    Fan Liu, Zhiyao Wang, Yue Qiu, Min Wei, Chunyan Li, Yikuan Xie, Le Shen, Yuguang Huang and Chao Ma

    Journal of Neuroinflammation 2017 14:70

    Published on: 31 March 2017

  13. Research

    In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

    Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. R...

    Teruyo Hosoya, Dai Fukumoto, Takeharu Kakiuchi, Shingo Nishiyama, Shigeyuki Yamamoto, Hiroyuki Ohba, Hideo Tsukada, Takatoshi Ueki, Kohji Sato and Yasuomi Ouchi

    Journal of Neuroinflammation 2017 14:69

    Published on: 29 March 2017

  14. Research

    Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo

    Astrocyte activation is a hallmark of traumatic brain injury resulting in neurological dysfunction or death for an overproduction of inflammatory cytokines and glial scar formation. Both the silent mating type...

    Dan Li, Nan Liu, Hai-Hua Zhao, Xu Zhang, Hitoshi Kawano, Lu Liu, Liang Zhao and Hong-Peng Li

    Journal of Neuroinflammation 2017 14:67

    Published on: 29 March 2017

  15. Short report

    Activation of FXR pathway does not alter glial cell function

    The nuclear receptor farnesoid-X-receptor (FXR; NR1H4) is expressed not only in the liver, gut, kidney and adipose tissue but also in the immune cells. FXR has been shown to confer protection in several animal...

    Stefanie Albrecht, Ann-Katrin Fleck, Ina Kirchberg, Stephanie Hucke, Marie Liebmann, Luisa Klotz and Tanja Kuhlmann

    Journal of Neuroinflammation 2017 14:66

    Published on: 28 March 2017

  16. Research

    Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model

    Severe hyperbilirubinemia is toxic during central nervous system development. Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced neurological damage and eventually death...

    Simone Vodret, Giulia Bortolussi, Jana Jašprová, Libor Vitek and Andrés F. Muro

    Journal of Neuroinflammation 2017 14:64

    Published on: 24 March 2017

  17. Research

    Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice

    La Crosse Virus (LACV) is a primary cause of pediatric viral encephalitis in the USA and can result in severe clinical outcomes. Almost all cases of LACV encephalitis occur in children 16 years or younger, ind...

    Clayton W. Winkler, Lara M. Myers, Tyson A. Woods, Aaron B. Carmody, Katherine G. Taylor and Karin E. Peterson

    Journal of Neuroinflammation 2017 14:62

    Published on: 24 March 2017

  18. Research

    NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

    NADPH oxidase (NOX2) is an enzyme system that generates reactive oxygen species (ROS) in microglia and macrophages. Excessive ROS production is linked with neuroinflammation and chronic neurodegeneration follo...

    James P. Barrett, Rebecca J. Henry, Sonia Villapol, Bogdan A. Stoica, Alok Kumar, Mark P. Burns, Alan I. Faden and David J. Loane

    Journal of Neuroinflammation 2017 14:65

    Published on: 24 March 2017

  19. Research

    Development of a model of Saint Louis encephalitis infection and disease in mice

    Flaviviruses are a genre of closely related viral pathogens which emerged in the last decades in Brazil and in the world. Saint (St.) Louis encephalitis virus (SLEV) is a neglected flavivirus that can cause a ...

    Rafael Elias Marques, Juliana L. Del Sarto, Rebeca P. F. Rocha, Giovanni F. Gomes, Allysson Cramer, Milene A. Rachid, Danielle G. Souza, Maurício L. Nogueira and Mauro M. Teixeira

    Journal of Neuroinflammation 2017 14:61

    Published on: 22 March 2017

  20. Research

    Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes

    Evidence from mice suggests that brain infiltrating immune cells contribute to neurodegeneration, and we previously identified a deleterious lymphocyte infiltration in Parkinson’s disease mice. However, this r...

    Vincent R. Parillaud, Guillaume Lornet, Yann Monnet, Anne-Laure Privat, Andrei T. Haddad, Vanessa Brochard, Amaury Bekaert, Camille Baudesson de Chanville, Etienne C. Hirsch, Christophe Combadière, Stéphane Hunot and Christian S. Lobsiger

    Journal of Neuroinflammation 2017 14:60

    Published on: 21 March 2017

  21. Short report

    Regulatory T cell frequency, but not plasma IL-33 levels, represents potential immunological biomarker to predict clinical response to intravenous immunoglobulin therapy

    Intravenous immunoglobulin (IVIG) is a polyspecific pooled immunoglobulin G preparation and one of the commonly used therapeutics for autoimmune diseases including those of neurological origin. A recent report...

    Mohan S. Maddur, Emmanuel Stephen-Victor, Mrinmoy Das, Praveen Prakhar, Varun K. Sharma, Vikas Singh, Magalie Rabin, Jamma Trinath, Kithiganahalli N. Balaji, Francis Bolgert, Jean-Michel Vallat, Laurent Magy, Srini V. Kaveri and Jagadeesh Bayry

    Journal of Neuroinflammation 2017 14:58

    Published on: 20 March 2017

  22. Research

    Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis

    Axonal damage and loss substantially contribute to the incremental accumulation of clinical disability in progressive multiple sclerosis. Here, we assessed the amount of Wallerian degeneration in brain tissue ...

    Shailender Singh, Tobias Dallenga, Anne Winkler, Shanu Roemer, Brigitte Maruschak, Heike Siebert, Wolfgang Brück and Christine Stadelmann

    Journal of Neuroinflammation 2017 14:57

    Published on: 17 March 2017

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