Fig. 7From: Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brainImmunohistochemical analysis showing the effect of curcumin (100 mg/kg BW) on the expression of claudin 4 in the brain of rats exposed to hypobaric hypoxia at 7620 m, for 24 h (a–d). Exposure to hypobaric hypoxia showed reduced expression of claudin 4 levels under hypoxia. Whereas, preconditioning with curcumin significantly maintained higher claudin 4 levels under hypoxia. Surprisingly, curcumin did not alter the claudin 4 levels under normoxia compared to control. The figure is representative of at least 4–5 animals from each group (40×). Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)Back to article page