Figure 5

Thioflavin-S labeling in coronal brain sections. A, B show hippocampus and C, D show cortex of 4-month-old mice; A, C are control mice, B, D, G are TGF-β1 mice, and E, F are a one-year-old APP mouse. Bars are 200 μm (A-D) or 100 μm (E-G). Thioflavin-positive material accumulated in the meninges and in vessels around the hippocampal fissure (HiF) in TGF-β1 mice. Vascular deposits in TGF-β1 mice were smoother in appearance and uniformly covered entire vascular segments, while in APP brains the deposits spread over the vessels in patches (compare E and F to G).