Density of thioflavin-S positive vessels along the hippocampus. A) Evolution with age. B) Effect of anti-inflammatory drugs. Values are the means ± SD; (*) p < 0.05, ns=non significant, ANOVA and Bonferroni posthoc analyses. N = 4–6 mice per group. The vascular accumulation of thioflavin-S-positive material increases between 2–4 months, and it is not altered by pioglitazone or ibuprofen.