Aβ and SAP immunoreactivity. The images show coronal sections of hippocampi from over one-year old APP mice (A, C), a 4-month-old TGF-β1 mouse (B) and a 9-month-old (D), stained with FC40 (A, B), 4G8 (C, D), thioflavin (E) or SAP (F). E, F are images of the same field in consecutive sections. FCA40 and 4G8 labeled Aβ plaques in APP mice and showed no specific reactivity in TGF-β1 mice. No SAP was detected in the thioflavin-reactive vascular deposits. Bar equals 100 μm. CC: corpus callosum. HiF: Hippocampal fissure; DG: dentate gyrus.