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Table 1 ELISA measurement of Aβ proteins in hippocampus

From: Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised

  2 months 4 months 9 months
  control control PIO IBU control
  T- T+ T- T+ T- T+ T- T+ T- T+
Aβ40 9.8 ± 1.7 10.1 ± 1.1 9.5 ± 2.5 9.6 ± 2.1 8.5 ± 2.2 8.3 ± 1.5 9.9 ± 0.9 10.5 ± 2.0 9.2 18.6
Aβ42 7.2 ± 1.5 7.2 ± 1.0 6.8 ± 2.7 6.9 ± 1.7 5.2 ± 1.5* 4.7 ± 0.7* 7.2 ± 1.3 7.2 ± 1.8 6.5 7.8
ratio 42/40 0.74 0.71 0.71 0.73 0.61 0.57 0.73 0.68 0.71 0.42
n 6 4 8 8 6 5 6 7 4 5
  1. Values are means in fmol / mg protein ± SD, except at 9 months where measurements were performed in pooled hippocampi. Results: i) no difference between T+ and T- groups at 2 or 4 months; ii) increase in Aβ40 in T+ at 9 months; iii) decrease of basal Aβ42 but not Aβ40 by pioglitazone in T- and T+ groups (*) p = 0.013, PIO versus control, two-way ANOVA analysis; iv) no effect of Ibuprofen. n, number of animals, T-, non transgenic mice; T+, TGF-β1 mice.