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Table 1 ELISA measurement of Aβ proteins in hippocampus

From: Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised

 

2 months

4 months

9 months

 

control

control

PIO

IBU

control

 

T-

T+

T-

T+

T-

T+

T-

T+

T-

T+

Aβ40

9.8 ± 1.7

10.1 ± 1.1

9.5 ± 2.5

9.6 ± 2.1

8.5 ± 2.2

8.3 ± 1.5

9.9 ± 0.9

10.5 ± 2.0

9.2

18.6

Aβ42

7.2 ± 1.5

7.2 ± 1.0

6.8 ± 2.7

6.9 ± 1.7

5.2 ± 1.5*

4.7 ± 0.7*

7.2 ± 1.3

7.2 ± 1.8

6.5

7.8

ratio 42/40

0.74

0.71

0.71

0.73

0.61

0.57

0.73

0.68

0.71

0.42

n

6

4

8

8

6

5

6

7

4

5

  1. Values are means in fmol / mg protein ± SD, except at 9 months where measurements were performed in pooled hippocampi. Results: i) no difference between T+ and T- groups at 2 or 4 months; ii) increase in Aβ40 in T+ at 9 months; iii) decrease of basal Aβ42 but not Aβ40 by pioglitazone in T- and T+ groups (*) p = 0.013, PIO versus control, two-way ANOVA analysis; iv) no effect of Ibuprofen. n, number of animals, T-, non transgenic mice; T+, TGF-β1 mice.