Figure 3

Dendritic degeneration of CA1 pyramidal neurons in mouse hippocampus. Neurolucida renderings of CA1 pyramidal neurons stained by Golgi method; blue is soma and first order dendrites, red is second order dendrites, green is third order dendrites, yellow is fourth order dendrites, brown is fifth order dendrites, and pink is sixth order dendrites. A. Typical pyramidal neuron 24 hr after ipsilateral ICV Saline injection. B and C. Pyramidal neurons following ipsilateral ICV LPS injection showing moderate (B) to severe (C) dendrite shortening and spine loss.