Table 1 Neuronal oxidative damage and dendritic degeneration in various knockout mice. Effects of ICV LPS treatment determined at 24 hr in mice homozygous deficient (knockout) for different genes or wildtype (wt) mice all on the C57Bl/6 genetic background (*P < 0.001 by Bonferroni-corrected repeated pair comparisons with ICV saline-exposed mice).

F ₄ -NeuroPs

Dendrite Length

Spine Density

352 + 53*

32 + 4*

37 + 6*

87 + 14

101 + 8

92 + 11

----

37 + 5*

51 + 8*

98 + 10

96 + 9

102 + 7

108 + 11

105 + 7

106 + 10

92 + 12

103 + 8

97 + 6

89 + 9

102 + 12

109 + 5