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Table 1 Neuronal oxidative damage and dendritic degeneration in various knockout mice. Effects of ICV LPS treatment determined at 24 hr in mice homozygous deficient (knockout) for different genes or wildtype (wt) mice all on the C57Bl/6 genetic background (*P < 0.001 by Bonferroni-corrected repeated pair comparisons with ICV saline-exposed mice).

From: Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo

Knockout Function                           Endpoints*
   F 4 -NeuroPs Dendrite Length Spine Density
None (wt) N/A 352 + 53* 32 + 4* 37 + 6*
CD14 Receptor 87 + 14 101 + 8 92 + 11
TLR-2 Receptor ---- 37 + 5* 51 + 8*
MyD88 Adaptor 98 + 10 96 + 9 102 + 7
p50 Initial Signal Cascade 108 + 11 105 + 7 106 + 10
iNOS Secondary Signaling 92 + 12 103 + 8 97 + 6
EP2 Secondary Signaling 89 + 9 102 + 12 109 + 5
  1. *% ICV saline-exposed; n > 5 in each group