Table 1 Effects of indomethacin plus vitamin E on total brain cortex levels of PGE2, TxB2 and IL-1β in Tg2576 mice. Mice were treated starting at 8-months of age until they were 15-month-old (n = 10 animals per group).
Placebo | Indomethacin Vitamin E | P | |
|---|---|---|---|
PGE2 (pg/mg tissue) | 92 ± 8 | 39 ± 5* | <0.01 |
TxB2 (pg/mg tissue) | 148 ± 10 | 15 ± 4* | <0.001 |
IL-1β (pg/mg protein) | 75 ± 12 | 33 ± 8* | <0.01 |