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Table 2 Ginkgolide B-treated SH-SY5Y cells are resistant to PAF or arachidonic acid: The survival of untreated cells, and cells treated with 1 μM ginkgolide B, subsequently incubated with different neurotoxins at the concentrations shown. Values shown represent the percentage survival of treated cells compared to untreated cells. Each value is the mean ± SD from triplicate experiments repeated three times (9 observations).

From: Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42

  conc untreated cells ginkgolide B-treated cells
medium   100 ± 3 98 ± 5
arachidonic acid (μM) 50 14 ± 2 46 ± 3**
  25 25 ± 5 72 ± 6**
  12.5 57 ± 3 93 ± 4**
hydrogen peroxide (μM) 20 3 ± 1 3 ± 2
  10 7 ± 2 8 ± 2
  5 46 ± 4 48 ± 6
PAF (μM) 40 18 ± 1 75 ± 7**
  20 37 ± 2 97 ± 3**
  10 62 ± 3 100 ± 2**
staurosporine (ng/ml) 20 40 ± 3 38 ± 3
  4 72 ± 4 69 ± 2
  0.8 93 ± 3 95 ± 3
  1. ** = Cell survival significantly greater (p < 0.05) than untreated cells incubated with neurotoxin.