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Table 2 Ginkgolide B-treated SH-SY5Y cells are resistant to PAF or arachidonic acid: The survival of untreated cells, and cells treated with 1 μM ginkgolide B, subsequently incubated with different neurotoxins at the concentrations shown. Values shown represent the percentage survival of treated cells compared to untreated cells. Each value is the mean ± SD from triplicate experiments repeated three times (9 observations).

From: Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42

 

conc

untreated cells

ginkgolide B-treated cells

medium

 

100 ± 3

98 ± 5

arachidonic acid (μM)

50

14 ± 2

46 ± 3**

 

25

25 ± 5

72 ± 6**

 

12.5

57 ± 3

93 ± 4**

hydrogen peroxide (μM)

20

3 ± 1

3 ± 2

 

10

7 ± 2

8 ± 2

 

5

46 ± 4

48 ± 6

PAF (μM)

40

18 ± 1

75 ± 7**

 

20

37 ± 2

97 ± 3**

 

10

62 ± 3

100 ± 2**

staurosporine (ng/ml)

20

40 ± 3

38 ± 3

 

4

72 ± 4

69 ± 2

 

0.8

93 ± 3

95 ± 3

  1. ** = Cell survival significantly greater (p < 0.05) than untreated cells incubated with neurotoxin.