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Table 3 Ginkgolides reduce prostaglandin E2 production: Levels of prostaglandin E2 produced by untreated SH-SY5Y cells, or cells pre-treated with 1 μM ginkgolide A, 1 μM ginkgolide B, 25 μM myricetin or 25 μM quercetin and thereafter incubated for 24 hours with 10 μM arachidonic acid, 10 μM amyloid-β1-42 10 μM HuPrP82-146 or 5 μM PAF. Each value is the mean level of prostaglandin E2 (pg/ml) ± SD from triplicate experiments repeated three times (9 observations).

From: Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42

  untreated HuPrP82-146 amyloid-β1-42 arachidonic acid PAF
Medium <20 362 ± 46 323 ± 39 438 ± 55 157 ± 38
ginkgolide A <20 66 ± 40** 57 ± 40** 234 ± 34** 45 ± 29**
ginkgolide B <20 <20** 25 ± 27** 145 ± 30** 36 ± 26**
myricetin <20 358 ± 64 327 ± 36 450 ± 30 149 ± 28
quercetin <20 349 ± 51 319 ± 28 442 ± 45 169 ± 29
  1. ** = Prostaglandin E2 production significantly less (p < 0.05) than in untreated cells.