Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer’s disease in Han Chinese

Table 1 Demographic and clinical characteristics of the study subjects

	AD (n = 1,133)	Control (n = 1,159)	P-value
Age at examination (years) (mean ± SD)	79.94 ± 8.12	74.48 ± 6.29
Age at onset (years) (mean ± SD)	75.01 ± 8.00		0.078^a
Gender, n (%)
Male	464 (41.0)	518 (44.7)	0.070
Female	669 (59.0)	641 (55.3)
MMSE (mean ± SD)	10.06 ± 3.82	28.26 ± 1.08	< 0.001
ApoE ϵ4 status, n (%)
ApoE ϵ4 carrier	315 (27.8)	158 (13.6)	< 0.001
ApoE ϵ4 noncarrier	818 (72.2)	1,001 (86.4)

^a P value was calculated with the age of onset for late-onset AD and age at examination for controls. AD, Alzheimer’s disease; ApoE ϵ4, apolipoprotein E ϵ4; MMSE, Mini-Mental State Examination.

ISSN: 1742-2094