Figure 5From: Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele High-fat diet did not induce atherosclerotic lesions in the aortic valve. A high-fat (HF) diet did not induce atherosclerotic lesions as evidenced by H & E stain of the aortic valve. Fatty streak plaques were absent in all three strains: (A) ApoE4-TR fed a HF diet, (B) ApoE3-TR fed a HF diet and (C) wild-type (WT) mice fed a HF diet. ApoE, apolipoprotein E; TR, targeted replacement. (D) Typical example image showing a WT mouse on normal diet. Representative photomicrographs are shown with original magnification of ×4. Scale bar = 500 μm.Back to article page