Figure 2

Cleaved caspase-3 expression after intracerebral hemorrhage. Representative cleaved caspase-3 western blots (A) and band density measurements (B) demonstrate reduction at 4, 24, and 72 hours after intrastriatal collagenase injection in mice given 7 mg/kg CNTO5048 or an equivalent volume of phosphate-buffered saline (PBS) via tail vein injection at 30 minutes after injury. (ANOVA; *P = 0.045 compared to PBS at 4 hours, ^# P = 0.046 compared to PBS at 72 hours; n = 3/group) CNTO4h, CNTO5048-treated mice at 4 hours after injury; CNTO24h, CNTO5048-treated mice at 24 hours after injury; CNTO72h, CNTO5048-treated mice at 72 hours after injury; GAPHD, glyceraldehyde-3-phosphate dehydrogenase; h, hours; PBS4h, PBS-treated mice at 4 hours after injury; PBS24h, PBS-treated mice at 24 hours after injury; PBS 72h, PBS-treated mice at 72 hours after injury.