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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage

Figure 3

Macrophage recruitment/microglial activation after intracerebral hemorrhage. Representative photos of F4/80 positive cells in ipsilateral hippocampus are shown from CNTO5048-treated (A) and phosphate-buffered saline-treated (B) mice. As a measure of microglial activation/macrophage recruitment, F4/80-positive cells were reduced in the ipsilateral hippocampus 7 days after intrastriatal collagenase injection in mice given 7 mg/kg CNTO5048 compared to those treated with an equivalent volume of phosphate-buffered saline via tail vein injection at 30 minutes after injury. (CNTO5048 versus vehicle: 3,880 ± 949 versus 4,953 ± 691 cells/mm3; t-test; *P = 0.049; n = 6/group).

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