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Figure 4 | Journal of Neuroinflammation

Figure 4

From: In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway

Figure 4

Matrix metalloproteinase (MMP)-1 and MMP-3 gene expression is suppressed by p38 inhibition. (A) Shows MMP-1 and (B) shows MMP-3 gene expression. mRNA from microglia stimulated for 24 hours with conditioned media from tuberculosis (TB)-infected monocytes (CoMTb) was analyzed by real-time PCR, normalized to 18S RNA and expressed as fold-change relative to mRNA from 24 hour-conditioned media from control monocytes (CoMCont). The mean ± SD from three experiments are shown. Data were analyzed by one-way analysis of variance, followed by Tukey’s multiple comparison test. * P <0.05, ** P <0.01.

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Journal of Neuroinflammation

ISSN: 1742-2094