Figure 4

The absence of adenosine receptor type A2 (A _2A R) prevents CX ₃ CL1 action. Graphs represent the average timecourse of CX₃CL1 effects on N-methyl-d-aspartate receptor component of field excitatory postsynaptic potentials (NMDA-fEPSPs). Points: mean ± SEM. Horizontal bar, CX₃CL1 application (5 nM). (A) In A₁R^−/− mice, application of CX₃CL1 enhanced NMDA-fEPSPs (n = 10/3). (B) The absence of A₃R did not interfere with CX₃CL1 action (n = 10/2). (C) In A_2AR^−/− mice, CX₃CL1 was ineffective (n = 11/3).