The absence of adenosine receptor type A2 (A
R) prevents CX
CL1 action. Graphs represent the average timecourse of CX3CL1 effects on N-methyl-d-aspartate receptor component of field excitatory postsynaptic potentials (NMDA-fEPSPs). Points: mean ± SEM. Horizontal bar, CX3CL1 application (5 nM). (A) In A1R−/− mice, application of CX3CL1 enhanced NMDA-fEPSPs (n = 10/3). (B) The absence of A3R did not interfere with CX3CL1 action (n = 10/2). (C) In A2AR−/− mice, CX3CL1 was ineffective (n = 11/3).