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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

Figure 3

Effect of neutral sphingomyelinase 2 on ischemic neuronal damage associated with cerebral ischemia. Neuronal damage in the rat CA1 hippocampal area was detected in the different groups that received different treatments using Nissl staining. (A) Postischemic reperfusion of different durations (3 d and 7 d) and control groups. (B) and (C) Injection with GW4869, imipramine (Lim) and their solvent into the lateral ventricle, respectively, followed by 7-d postischemic reperfusion. (D) Normal group with daunorubicin (DNR) stimulus for 24 h. (E) Effect of neutral sphingomyelinase 2 (nSMase2) small interfering RNA (siRNA) and control siRNA on the rat CA1 hippocampal neurons postischemia. (F) Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling assays showing apoptosis in the rat CA1 hippocampal neurons postischemia and effect of nSMase2 siRNA on them (n = 4).

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Journal of Neuroinflammation

ISSN: 1742-2094