Experimental groups | Distribution of neurological deficit scores post-MCAO | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 hour | 24 hours | 48 hours | 72 hours | 96 hours | |||||||||||||||||||||
0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | |
WT (n = 11) | 0 | 0 | 4 | 7 | 0 | 0 | 4 | 1 | 6 | 0 | 0 | 5 | 3 | 6 | 0 | 0 | 5 | 5 | 1 | 0 | 0 | 5 | 2 | 4 | 0 |
PD-L1-/- (n = 12) | 0 | 1 | 10 | 1 | 0 | 0 | 9 | 2 | 1 | 0 | 0 | 11 | 0 | 1 | 0 | 0 | 11 | 1 | 0 | 0 | 0 | 12 | 0 | 0 | 0 |
PD-L2-/- (n = 12) | 0 | 0 | 6 | 6 | 0 | 0 | 3 | 8 | 1 | 0 | 0 | 4 | 8 | 0 | 0 | 0 | 7 | 2 | 3 | 0 | 0 | 7 | 1 | 1 | 3 |
 | Median neurological deficit scores post-MCAO | ||||||||||||||||||||||||
 | 1 hour ( P = 0.013) | 24 hours ( P = 0.044) | 48 hours ( P = 0.031) | 72 hours ( P = 0.062) | 96 hours ( P = 0.020) | ||||||||||||||||||||
WT (n = 11) | 3 | 3 | 2 | 2 | 2 | ||||||||||||||||||||
PD-L1-/- (n = 12) | 2a | 1a | 1 | 1 | 1 | ||||||||||||||||||||
PD-L2-/- (n = 12) | 2.5 | 2 | 2 | 1 | 1 |