Leukocyte infiltration in experimental stroke

Table 3 Amount of macrophages/microglia (normalized) at different time points post- ischemia listed according to duration of occlusion (tMCAO and pMCAO)

Occlusion time	Amount of macrophages/microglia (days of survival)										n	Strain	Marker	Reference
	<1	1	2	3	4	5	7	14	21	≥30
30 minutes^Δ	++	++	++	+++							5	C57Bl/6	Iba-1	[25]
30 minutes		+	++		+++		++				4	C57Bl/6	F4/80	[31]
30 minutes		+	++		+++		++				4	C57Bl/6	F4/80	[32]
60 minutes^Δ	++	++	++	+++							6	C57Bl/6	Iba-1	[25]
60 minutes^Δ		+		+++			++				5	C57Bl/6	Iba-1	[27]
120 minutes	+	+		+++							8	Wistar	CD68	[37]
120 minutes		-		++			+++				7	Sprague–Dawley	CD68	[39]
pMCAO^Δ	-	-	-	++	+++	++					6	Wistar	H&E	[26]
pMCAO				+			++	+++	++	++	6	Sprague–Dawley	CD68	[40]
pMCAO		+		+++			+++	+++		++	5	Wistar and Lewis	CD68	[41]

Crosses represent the following amount of cells presented as percentage of the highest cell number: +, 25 to 49%; ++, 50 to 94%; +++, 95 to 100%; -, <25%. ^ΔWeighted average. H&E, hematoxylin and eosin; n, number of animals included; pMCAO, permanent middle cerebral artery occlusion; tMCAO, transient middle cerebral artery occlusion.

ISSN: 1742-2094