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Table 3 Amount of macrophages/microglia (normalized) at different time points post- ischemia listed according to duration of occlusion (tMCAO and pMCAO)

From: Leukocyte infiltration in experimental stroke

Occlusion time Amount of macrophages/microglia (days of survival) n Strain Marker Reference
  <1 1 2 3 4 5 7 14 21 ≥30     
30 minutesΔ ++ ++ ++ +++        5 C57Bl/6 Iba-1 [25]
30 minutes   + ++   +++   ++     4 C57Bl/6 F4/80 [31]
30 minutes   + ++   +++   ++     4 C57Bl/6 F4/80 [32]
60 minutesΔ ++ ++ ++ +++        6 C57Bl/6 Iba-1 [25]
60 minutesΔ   +   +++    ++     5 C57Bl/6 Iba-1 [27]
120 minutes + +   +++        8 Wistar CD68 [37]
120 minutes   -   ++    +++     7 Sprague–Dawley CD68 [39]
pMCAOΔ - - - ++ +++ ++      6 Wistar H&E [26]
pMCAO     +    ++ +++ ++ ++ 6 Sprague–Dawley CD68 [40]
pMCAO   +   +++    +++ +++   ++ 5 Wistar and Lewis CD68 [41]
  1. Crosses represent the following amount of cells presented as percentage of the highest cell number: +, 25 to 49%; ++, 50 to 94%; +++, 95 to 100%; -, <25%. ΔWeighted average. H&E, hematoxylin and eosin; n, number of animals included; pMCAO, permanent middle cerebral artery occlusion; tMCAO, transient middle cerebral artery occlusion.