Figure 5

Evaluation of infiltrates and neuronal plaques in the retina. (A) H&E-stained retina crosssections of CO (left) and EAE animals (right, n = 5 to 7 eyes/group). No difference between CO and EAE in retinal structure and no neuronal tangles and plaques were observed. (B) Quantification of the retinal layer thickness (n = 5 to 7 eyes/group). No difference was noted in the thickness of the layers. (C) Bielschowsky’s silver stain of retina sections of CO and EAE animals (n = 5 to 7 eyes/group). The retinal structure of EAE animals was not altered compared to CO and no neuronal plaques were noted. Scale bars: 25 μm. CO, control; EAE, experimental autoimmune encephalomyelitis; GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer; OPL, outer plexiform layer; OS, outer segments.