Skip to main content
Figure 3 | Journal of Neuroinflammation

Figure 3

From: Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter

Figure 3

Neurons exposed to glutamate reversibly and dose-dependently exhibit focal swellings of their neurites, that is neuronal beading. (A-D) L-glutamate exposition (0, 100 and 1,000 μM) for 30 minutes followed by washout for 30 minutes dose-dependently and reversibly increased the proportion of cultured neurons showing focal swellings of their neurites, that is neuronal beading. (A-C) Representative images showing cultured neurons (MAP2, green; DAPI, blue) before (A ) and after (B ) 30 minutes of exposition to 100 μM glutamate as well as after another 30 minutes of wash-out (C ). (D ) Fraction of beading neurons under distinct experimental conditions (n = 5 respectively).

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094