Axonal injury and axonal loss in experimental autoimmune encephalomyelitis (EAE) in mice deficient for the urokinase plasminogen activator (uPA
), or the urokinase plasminogen activator receptor (uPAR
) compared with EAE wild-type (WT) mice. Rsults are presented as percentage distribution of severity. (A,C) uPAR−/− mice exhibited (A) similarly active axonal injury (AI) and (C) significantly greater axonal loss (AL). (B,D) uPA−/− mice exhibited (B) more severe AI and (D) more AL. *P<0.05, **P<0.001.