Figure 4

Lectin-positive microglia/macrophages in spinal cords of mice deficient for the urokinase plasminogen activator receptor (uPAR ^−/− ) and of wild-type (WT) mice. (A) Significant increase in numbers of lectin-positive cells (microglia/macrophages) in the spinal cords of uPAR^−/− animals compared with the WT mice (***P<0.0001). Representative photographs showing perivascular and parenchymal lectin-positive microglia/macrophages (arrows) in (B,C) WT and (D,E) uPAR^−/− animals.