Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature

Table 1 Western data of D2-40, LYVE-1, Prox-1, VEGFR-3, VEGF-D and Ang-2 levels in MS and its animal models

	D2-40	LYVE-1	PROX-1	VEGFR-3	VEGF-D	Ang-2
MS brain (RRMS)	↑	↑	↑	↓	↑	↑
TMEV brain	NA	-	-	↑	↑	-
PLP brain^a	NA	-	-	-	↑	-
RRMS serum	↑	↑	↓	↑	↑	↑
SPMS serum	↑	-	↓	↑	↑	-
TMEV serum	NA	-	↑	↑	↑	↑
PLP serum^a	NA	-	-	-	-	-

Con vs. RRMS human brain samples; Con vs. SPMS and RRMS serum samples; Control vs. TMEV-IDD; and naïve vs. CFA, PLP serum and brain samples. For naïve vs. CFA vs. CFA+PLP-EAE only proteins that showed statistical difference between all the 3 groups were shown.
^aCFA + PLP is significantly different from both Naïve and CFA alone.

ISSN: 1742-2094