Figure 2
From: Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients
Dynamics of 23 genes consistently modulated in expression during glatiramer acetate (GA) therapy. A subset of the 463 filtered genes appeared repeatedly as differentially expressed in consecutive time point comparisons. The graph shows the mean mRNA expression dynamics of 23 genes that were repeatedly found expressed at significantly higher or lower levels across at least two different time points compared to the pre-treatment levels. There were 18 up-regulated genes and 5 down-regulated genes (CD34, RPA4, HMGB1L4, RARS and BAZ2B). The MAID-score, a fold-change variant that is calculated from the data of all patients, is represented on the y-axis and the time points are represented on the x-axis.