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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain

Figure 3

hBD-1 is apparent in astroglial cells of the hippocampus. The expected localization of hBD-1 brown reaction product in glial cells was demonstrated in AD cases by colocalization with an antibody to GFAP (blue) (A, inset). Arrows mark the numerous glial cells containing both GFAP and hBD-1, while arrowheads denote neurons containing only the brown hBD-1 reaction product. Specificity of the antibody and method used for detection of hBD-1 was tested on tissue sections of human epidermal skin cells, known to express hBD-1, as a positive control (B). Scale bar (inset) = 50 μm.

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