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Figure 6 | Journal of Neuroinflammation

Figure 6

From: TSG (2,3,4’ ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia

Figure 6

Effects of TSG on the nuclear translocation of nuclear factor κB (NF-κB) and activation of mitogen-activated protein kinase (MAPK) signals in BV-2 cells. (A) Effects of TSG on NF-κB expression in the cytoplasm in lipolysaccharide (LPS)/TSG-treated BV-2 cells. (B) Quantitative analysis of NF-κB amount in the cytoplasm (n = 3, *P < 0.05 versus control or the TSG alone-treated group). (C) Effects of TSG on NF-κB expression in the nucleus in LPS/TSG-treated BV-2 cells. (D) Quantitative analysis of the amount of NF-κB in the nucleus (n = 3, *P < 0.05 versus control, **P < 0.01 versus the TSG alone-treated group). (E) Representative images showing the effect of TSG (50 μM, 30 minutes) on LPS-induced increase in ERK1/2, JNK, and p38 phosphorylation level in BV-2 cells. Experiments were performed three times independently. All data were shown as mean ± standard error. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

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