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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Figure 6

Global HI induced region-specific vulnerability of O4-positive pre-oligodendrocytes (preOLs; late oligodendrocyte progenitors and immature oligodendrocytes). Regions of interest are depicted in Figure  2. (A) Global HI significantly increased the density of total and degenerative preOLs in the medial periventricular white matter (PVWM). (B) Sham, medial PVWM; preOL with mature phenotype (black arrow). (C) HI, medial PVWM; preOLs with degenerative phenotype (white arrowheads). (D) Global HI significantly decreased density of total and immature preOLs in the intermediate PVWM. (E) Sham, intermediate PVWM; preOLs with immature phenotype (black arrow heads). (F) HI, intermediate PVWM; preOLs with degenerative phenotype (white arrow heads) and apoptotic preOL (white arrow). (G) Global HI significantly increased the density of degenerative preOLs in the lateral PVWM, density of total preOLs was unchanged. (H) Sham, lateral PVWM; preOL with mature phenotype (black arrow). (I) HI, lateral PVWM; preOL with degenerative (white arrow head) and apoptotic (white arrow) phenotype. (J) Global HI significantly reduced the density of total and immature preOLs subcortical white matter (SCWM). (K) Sham, SCWM; preOLs with immature phenotype (black arrow heads). (L) HI, SCWM; reduced density of preOLs with immature phenotype (black arrow heads) and disturbance of O4-positive myelin sheath organization. Scale bar all images = 50 μm. (A, D, G, J) Geometric means ± 95% CI are depicted. *P ≤0.05, # P ≤0.01, ‡ P ≤0.001, NS, non-significant. HI = hypoxia-ischemia.

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