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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Figure 8

Global HI induced significant invasion of MPO-positive cells (neutrophils) into the hippocampus, PVWM and SCWM. Invading neutrophils were predominantly localized in the perivascular zone. (A) Global HI caused a significant increase in the total number of MPO-positive cells in the hippocampus, mainly attributable to a profound increase in the number of perivascular MPO-positive cells; (B) Sham, hippocampus; perivascular MPO-positive cell (black arrow head); (C) HI, hippocampus; profound increase in the number of perivascular MPO-positive cells (black arrow heads); (D) Global HI caused a significant increase in the total number of MPO-positive cells in the PVWM, attributable to a significant increase in the number of perivascular MPO-positive cells; (E) Sham, PVWM; perivascular (black arrow head) and interstitial (black arrow) MPO-positive cells; (F) HI, PVWM; marked increase in perivascular MPO-positive cells (black arrow heads); (G) Global HI caused a significant increase in the total number of MPO-positive cells in the SCWM, attributable to a significant increase in the number of intravascular, perivascular and interstitial MPO-positive cells; (H) Sham, SCWM; intravascular MPO-positive cells (white arrow heads); (I) HI, SCWM; intravascular (white arrow heads), perivascular (black arrow heads) and interstitial (black arrow) MPO-positive cells. Scale bar all images = 50 μm. (A, D, G) Geometric means ± 95% CI are depicted. *P ≤0.05, # P ≤0.01, ‡ P ≤0.001, NS, non-significant. HI = hypoxia-ischemia.

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