Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

Table 1 Estimated fixed and random effect parameters of the piecewise (mixed) regression model

Parameters	(95% CI)
(Fixed and random effects)	n = 16
Intercept	2.60 (2.19, 3.00) ‡
Group (Sham)	−7.14 (−1.39, -0.03) *
Dummy pre-post UCO (pre-time)	−0.63 (−0.95, -0.32) ‡
Group*pre-post dummy	0.65 (0.27, 1.02) ‡
Pre-UCO time	−0.01 (−0.20, 0.18) NS
Post-UCO time	0.29 (0.12, 0.46) ‡
Post-UCO time (2)	−0.12 (−4.84, 1.73) ‡
Post-UCO time (3)	0.01 (0.00, 0.02) ‡
Residual variance	0.03 (0.02, 0.05) ‡
Random intercept variance, pre-UCO time	0.29 (0.12, 0.68) *
Random slope variance, pre-UCO time	0.03 (0.01,0.10) *
Random slope variance, post-UCO time HI	0.007 (0.002, 0.20)*

Estimated fixed and random effect parameters of the piecewise (mixed) regression model (Outcome variable: mean IBI length, on the log scale. Covariance structure: diagonal). The fixed effect regression coefficients β for the continuous time variables indicate average changes in mean IBI length per day. For nominal variables, β represent average changes in the highlighted category (in brackets) with respect to the reference group (omitted). *P ≤0.05, # P ≤0.01, ‡ P ≤0.001, NS, non-significant.

ISSN: 1742-2094