Figure 8From: Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation The Nrf2 pathway is not activated after proinflammatory stimulation of astrocytes. The canonical pathway of the Nrf2 transcription factor was analyzed with Ingenuity software. Left panel shows downregulated (green) and upregulated (red) genes in cytokine-activated astrocytes; right panel shows the same genes in MCM[+]-activated astrocytes.Back to article page