Figure 1
From: Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1G93Amice
SSM treatment increases motor neuron survival in hSOD1G93Amice. SSM (2.5 μℓ/g) was administered bilaterally at acupoint ST36 three times per week for two weeks. Photomicrographs of Nissl (A) and FJB (C) staining of the lumbar spinal cord. Each right-hand column depicts a magnified image of the rectangular region of the corresponding image in the left column. The numbers of viable motor neurons (B) and degenerating FJB-positive glial cells (D) were counted, as described in the magnified spinal cord column. (E) Photomicrographs of MAP2 staining of the lumbar spinal cord. Each right-hand column depicts a magnified image of the rectangular region of the corresponding image in the left column. (F) Quantitative analysis of MAP2-positive cells each magnified column. Control (Sal) animals were bilaterally injected with an equivalent volume of saline at the ST36 acupoint. The data are presented as the means ± SEM (N = 6 animals/genotype). Statistical significance was assessed via t-test. ***P < 0.001 compared to the saline-treated group. Magnification: 100×. Bar = 500 μm. Sal: saline-treated hSOD1G93A mice, SSM: Scolopendra subspinipes mutilans (SSM)-treated hSOD1G93A mice.