Brain pathology after controlled cortical impact (CCI): the effect of FP receptor blockade. (A) Representative photographs of cresyl violet-stained brain sections from sham and CCI-injured WT mice demonstrating cortical injury and hippocampal swelling in the areas between bregma one and two 48 hours after injury. (B) Quantitative analysis of the hippocampal area demonstrating a significant increase in relative hippocampal areas normalized to contralateral side in the ipsilateral hemisphere and significant decrease of hippocampal swelling in AL-8810- (10 mg/kg) treated mice 48 hours after CCI. (C) Representative photographs of cresyl-violet stained brain sections from sham and CCI-injured WT mice demonstrating cortical cavitation and remaining hippocampal swelling in the areas ten days after injury. (D) Quantitative analysis of relative hippocampal areas normalized to the contralateral side in saline- and AL-8810- (10 mg/kg) treated WT mice that underwent CCI or sham. The data demonstrate a significant hippocampal swelling ten days after injury compared with sham group, whereas there are no significant differences between relative hippocampal area values between two treatment groups that underwent CCI, between sham and either of these treatment groups, or between CCI groups with saline and drug treatments. Data are presented as mean ± SEM, *P < 0.05, **P < 0.01, versus saline-treated sham group, and #P < 0.05, versus saline-treated CCI group, one-way ANOVA followed by Tukey's multiple comparison test (n = 7 to 9).