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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Prostaglandin F FP receptor antagonist improves outcomes after experimental traumatic brain injury

Figure 2

FP receptor blockade improves behavioral outcomes after controlled cortical impact (CCI). (A) Neurological deficit scores (NDS) in CCI-injured WT mice 24 and 48 hours after injury. Post-treatment AL-8810 (10 mg/kg) significantly improved NDS at both time points, **P < 0.01, ***P < 0.001, Kruskal-Wallis ANOVA on ranks followed by Dunn's multiple comparison test (n = 5 to 9). (B) Comparison of NDS between a single dose of AL-8810 (10 mg/kg) 24 hours after injury and two doses of AL-8810 (10 mg/kg, once a day) 24 and 48 hours after injury in the same mice that underwent CCI. The data were obtained in a separate cohort of mice. ‘ns’ denotes not statistically different, Wilcoxon matched-pairs signed rank test (P = 0.6, n = 8). (C) Changes in grip strength in CCI-injured WT mice 24 and 48 hours after injury. Post-treatment AL-8810 (10 mg/kg) significantly improved CCI-induced impairment in grip strength at 24 hours. *P < 0.05, paired Student’s t-test versus baseline. #P < 0.05, one-way ANOVA followed by Tukey's multiple comparison test, n = 3 in each group.

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