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Table 1 Neurological deficit scoring

From: Prostaglandin F FP receptor antagonist improves outcomes after experimental traumatic brain injury

Test

Body symmetry

Gait

Circling behavior

Climbing

Front limb symmetry

Compulsory circling

Score

Mouse allowed to move freely on the elevated open rectangular plain surface for two to five minutes

Mouse placed on the gripping surface with 45° angle for 60 seconds

Mouse suspended by tail for 30 seconds

Mouse suspended by tail with front limbs on bench for 30 seconds

0

normal

normal

not present

normal

not present

not present

1

tilting on one side

stiff, inflexible

predominant one-sided turns

climbs with strain

slight asymmetry

tendency to turn to one side

2

moderate asymmetry

limping

circles to one side not constantly

holds on slope

marked asymmetry

circles to one side

3

prominent asymmetry

trembling

circles to one side constantly

slides down slope, unsuccessful effort to prevent fall

prominent asymmetry

pivots to one side sluggishly

4

extreme asymmetry

does not walk

pivoting, swaying, or no movement

slides down immediately, no effort to prevent fall

slight asymmetry, no body or limb movement

does not advance