From: Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury
Test | Body symmetry | Gait | Circling behavior | Climbing | Front limb symmetry | Compulsory circling |
---|---|---|---|---|---|---|
Score | Mouse allowed to move freely on the elevated open rectangular plain surface for two to five minutes | Mouse placed on the gripping surface with 45° angle for 60 seconds | Mouse suspended by tail for 30 seconds | Mouse suspended by tail with front limbs on bench for 30 seconds | ||
0 | normal | normal | not present | normal | not present | not present |
1 | tilting on one side | stiff, inflexible | predominant one-sided turns | climbs with strain | slight asymmetry | tendency to turn to one side |
2 | moderate asymmetry | limping | circles to one side not constantly | holds on slope | marked asymmetry | circles to one side |
3 | prominent asymmetry | trembling | circles to one side constantly | slides down slope, unsuccessful effort to prevent fall | prominent asymmetry | pivots to one side sluggishly |
4 | extreme asymmetry | does not walk | pivoting, swaying, or no movement | slides down immediately, no effort to prevent fall | slight asymmetry, no body or limb movement | does not advance |