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Figure 1 | Journal of Neuroinflammation

Figure 1

From: ADAMTS proteoglycanases in the physiological and pathological central nervous system

Figure 1

Roles of ADAMTS proteoglycanases in the physiological and pathological central nervous system. Schematic representation of described (filled lines)/hypothetical (dotted lines) roles of ADAMTS proteoglycanases in the physiological (green) and pathological (red) CNS, with corresponding major references listed below. This schema also illustrates that ADAMTS proteoglycanases can achieve several functions in the physiological and pathological CNS via the cleavage of their substrates, so far CSPGs or Reelin, but also independently of their proteolytic activity. ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; CNS, central nervous system; CSPGs, chondroitin sulfate proteoglycans.

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