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Figure 1 | Journal of Neuroinflammation

Figure 1

From: The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

Figure 1

Aβ ELISA of Tg-5xFAD and Tg-5xFAD/MBP -/- mice of different extraction pools. Pulverized brain was sequentially extracted with TBS buffer, TBS with 1% Triton X-100, and 5M Guanidine-HCl for soluble, membrane, and insoluble Aβ. The amount of Aβ did not differ in soluble and membrane fractions but was significantly decreased in the insoluble fraction of bigenic Tg-5xFAD/MBP-/- mice. The reduction was ≈ 8-fold for Aβ40 and ≈ 30-fold for Aβ42. Data presented are the mean ± SEM. of 10 or 11 mice per group. *** P = 0.00013. i, insoluble; m, membrane-associated; s, soluble.

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Journal of Neuroinflammation

ISSN: 1742-2094