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Figure 4 | Journal of Neuroinflammation

Figure 4

From: The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

Figure 4

No significant difference in the level of intraneuronal Aβ between Tg-5xFAD and Tg-5xFAD/MBP -/- mice. To assess the level of intraneuronal Aβ, sections were pretreated with formic acid and incubated with an oligomer specific antibody, OC. Prominent cell body Aβ staining was observed in layer V of cortex in both (A) Tg-5xFAD and (B) Tg-5xFAD/MBP-/- mice. (C) Cortical neurons with positive iAβ were counted, no difference was observed between different genotypes. Scale bar, 100 μm. Data presented are the mean ± SEM of 4 or 5 mice per group.

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