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Figure 6 | Journal of Neuroinflammation

Figure 6

From: The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

Figure 6

Increased reactive astrocytes in Tg-5xFAD/MBP -/- mice are associated with the absence of MBP. Immunostaining for GFAP showed increased reactive astrocytes in Tg-5xFAD/MBP-/- mice (C) compared with wild-type mice (A) and Tg-5xFAD mice (B). Increased reactive astrocytes were also observed in MBP-/- mice (D). Left panels, overviews (scale bar, 1 mm); right panels, higher magnification (scale bar, 50 μm). (E) Levels of immunostaining of the selected areas in (A) to (D) were quantified by Image J software and represented as % of area. Data presented are the mean ± SEM of 3 to 5 mice per group. *P = 0.014, ***P = 0.00,003. (F) Representative immunoblots for GFAP in total brain homogenates from the different mice. (G) Quantitation of GFAP from immunoblots. Data presented are the mean ± SEM of three mice per group. *P = 0.03.

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Journal of Neuroinflammation

ISSN: 1742-2094