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Figure 7 | Journal of Neuroinflammation

Figure 7

From: The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice

Figure 7

Increased activated microglia in Tg-5xFAD/MBP -/- mice are associated with the absence of MBP. Immunostaining with 5D4 keratan sulfate antibody showed increased activated microglia in Tg-5xFAD/MBP-/- mice (C) compared with wild-type mice (A) and Tg-5xFAD mice (B). Increased activated microglia were also observed in MBP-/- mice (D). Left panels, overviews (scale bar, 1 mm); right panels, higher magnification (scale bar, 50 μm). (E) Levels of immunostaining of the selected area in (A) to (D) were quantified by Image J software and represented as % area fraction. Data presented are the mean ± SEM of 3 to 5 mice per group. *P = 0.0106, **P = 0.0123.

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Journal of Neuroinflammation

ISSN: 1742-2094