Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo

Table 1 Characteristics of fluorescent imaging agents

Agent	Description	M.W.	Peak Ex/Em	Biological activity
Cat B 680 FAST	Cathepsin-activatable	33 kDa	675/693	Macrophage/microglia
MMPSense 750 FAST	Metalloproteinase-activatable	43 kDa	749/775	Macrophage/microglia
ProSense 750 EX	Cathepsin-activatable	450 kDa	750/770	Macrophage/microglia
ReninSense 680 FAST	Renin-activatable	43 kDa	675/693	T cell RAS activity
AngioSense 680	Vascular agent	250 kDa	680/700	BBB breakdown
AngioSense 750 EX	Vascular agent	70 kDa	750/770	BBB breakdown

ISSN: 1742-2094