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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

Figure 1

Putative mechanisms involving the synthesis of reactive oxygen species (ROS) and their bidirectional interaction with neuroinflammation in major depressive disorder. This figure shows potential mechanistic links among ROS, inflammation, and hyperglutamatergia. Abbreviations: BBB, blood-brain barrier; COX2, cyclo-oxygenase 2; CRH, corticotropin-releasing hormone; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; MMP, matrix metalloproteinase; NAD(P)H, nicotinamide adenosine dinucleotide phosphate; NMDAR, N-methyl-D-aspartate receptor; NO, nitric oxide; PLA2, phospholipase A2.

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Journal of Neuroinflammation

ISSN: 1742-2094