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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain

Figure 2

Nesting behavior is impaired in PLP-ISEdel mice. (A) Representative images of the types of nests built by the wild-type (WT) mice and the PLP-ISEdel mice. (B) At 2-months-old and at 4-months-old, the PLP-ISEdel mice showed a significant impairment in the quality of the nest built compared to the age-matched WT mice. (2-month-old WT (n = 14) versus PLP (n = 16) *P = 0.024; 4-month-old WT (n = 10) versus PLP (n = 6) **P = 0.0039).

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Journal of Neuroinflammation

ISSN: 1742-2094