CD68 and major histocompatibility complex class II (MHCII) histopathology is increased in the PLP-ISEdel mice. (A) The heat map shows CD68 quantification with 2-month-old wild-type (WT) mice used as 100%. Mean ± SEM for each brain region is indicated (n = 5 to 6 per group). (B) CD68+ cells were found in the white and gray matter regions of the cerebellum. (C) Quantification of the MHCII staining in the outlined regions, expressed as percent of 2-month-old WT as 100%. Mean ± SEM for each brain region is indicated (n = 5 to 6 per group). (D) A representative photomicrograph shows MHCII+ cells in the corpus callosum of a 4-month-old PLP-ISEdel mouse.