Amyloid precursor protein (APP) accumulation is seen in the 4-month-old PLP-ISEdel mice. (A) In 4-month-old wild-type (WT) mice, APP staining was localized to the neuronal cell body and no APP+ spheroids were found. In 4-month-old PLP-ISEdel mice, many APP+ spheroids were seen in the thalamus. The black box shows the region of the higher power image on the right. (B) In the striatum, APP accumulation was seen in the white matter tracks in the 4-month-old PLP-ISEdel mice but not in the WT mice. Arrow indicates the APP+ spheroid shown in the higher power image on the right.