Brain region | C57BL/6Â J | PLP-ISEdel | Two-way ANOVA | ||||
---|---|---|---|---|---|---|---|
2mo | 4mo | 2mo | 4mo | Geno | Age | Inter | |
IBA1 IHC | |||||||
Cerebellum gm | 100 ± 17 | 293 ± 68 | 82 ± 24 | 293 ± 68 | ns | ** | ns |
Cerebellum wm | 100 ± 35 | 424 ± 181 | 235 ± 35 | 1,058 ± 297 | * | ** | ns |
Medulla | 100 ± 21 | 324 ± 127 | 272 ± 41 | 940 ± 216 | ** | ** | ns |
Pons | 100 ± 23 | 237 ± 116 | 274 ± 52 | 512 ± 55 | ** | * | ns |
Midbrain | 100 ± 35 | 243 ± 71 | 261 ± 26 | 540 ± 131 | ** | * | ns |
Thalamus | 100 ± 30 | 161 ± 55 | 193 ± 14 | 256 ± 75 | ns | ns | ns |
Striatum | 100 ± 24 | 323 ± 103 | 87 ± 7 | 335 ± 74 | ns | ** | ns |
Corpus callosum | 100 ± 18 | 195 ± 41 | 152 ± 44 | 294 ± 84 | ns | * | ns |
Cortex | 100 ± 14 | 143 ± 17 | 81 ± 16 | 136 ± 22 | ns | * | ns |
Hippocampus | 100 ± 34 | 200 ± 51 | 76 ± 4 | 141 ± 38 | ns | * | ns |
CD68 IHC | |||||||
Cerebellum gm | 100 ± 47 | 500 ± 194 | 375 ± 88 | 1,539 ± 398 | ** | ** | ns |
Cerebellum wm | 100 ± 31 | 346 ± 67 | 1,464 ± 127 | 11,607 ± 214 | **** | **** | *** |
Medulla | 100 ± 11 | 323 ± 35 | 1,571 ± 166 | 7,888 ± 1294 | **** | **** | *** |
Pons | 100 ± 20 | 433 ± 50 | 1,161 ± 83 | 6,121 ± 1107 | **** | **** | *** |
Midbrain | 100 ± 21 | 260 ± 26 | 515 ± 76 | 2,960 ± 379 | **** | **** | **** |
Thalamus | 100 ± 10 | 251 ± 19 | 498 ± 78 | 2,075 ± 257 | **** | **** | **** |
Striatum | 100 ± 29 | 218 ± 17 | 157 ± 42 | 1,142 ± 213 | *** | **** | ** |
Corpus callosum | 100 ± 15 | 208 ± 22 | 690 ± 96 | 2,715 ± 285 | **** | **** | **** |
Cortex | 100 ± 25 | 427 ± 115 | 308 ± 62 | 1,301 ± 285 | *** | **** | ** |
Hippocampus | 100 ± 45 | 320 ± 24 | 104 ± 16 | 513 ± 50 | ** | **** | ** |
MHCII IHC | |||||||
Cerebellum gm | 100 ± 46 | 336 ± 63 | 797 ± 320 | 632 ± 386 | ns | ns | ns |
Cerebellum wm | 100 ± 75 | 296 ± 156 | 493 ± 275 | 891 ± 223 | ns | * | ns |
Medulla | 100 ± 40 | 351 ± 57 | 556 ± 281 | 1,551 ± 280 | * | * | ns |
Pons | 100 ± 53 | 437 ± 100 | 1,587 ± 211 | 963 ± 291 | *** | ns | * |
Midbrain | 100 ± 33 | 99 ± 22 | 970 ± 250 | 1,139 ± 185 | **** | ns | ns |
Thalamus | 100 ± 36 | 109 ± 25 | 569 ± 200 | 841 ± 251 | ** | ns | ns |
Striatum | 100 ± 25 | 61 ± 14 | 326 ± 150 | 790 ± 318 | * | ns | ns |
Corpus callosum | 100 ± 36 | 65 ± 19 | 463 ± 98 | 2,505 ± 1148 | ns | ns | ns |
Cortex | 100 ± 38 | 197 ± 54 | 398 ± 126 | 474 ± 87 | ** | ns | ns |
Hippocampus | 100 ± 47 | 738 ± 232 | 1,482 ± 692 | 1,677 ± 839 | ns | ns | ns |