Figure 3

Schematic of potential central interactions involved in IL-1β hypophagia, showing stimulation (solid arrows) of anorexigenic mediators and inhibition (dashed arrows) of orexigenic mediators. In normal rats, loss of the serotonergic influence, as induced by nitric oxide stimulation (present results), does not affect IL-1β hypophagia, while the loss of serotonin is not compensated in obese rats, leading to abolition of IL-1β hypophagia [15].