Figure 8From: Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice IT IFNβ transiently reverses L5 SNL induced tactile allodynia. Twelve days following L5 SNL, C57BL/6 mice received IFNβ either (A) intrathecally or (B) intraperitoneally. (A) IT IFNβ (100 ng/5 μL) transiently reversed the tactile allodynia present at 12 days post-L5 SNL in C57BL/6 mice. (B) IFNβ i.p. (7,500 U/100 μL) did not affect the tactile allodynia present at 12 days post-L5 SNL in C57BL/6 mice. Data expressed as mean ± SEM (n = 3–4 mice/group) and analyzed via 2-way ANOVA. Following IFNβ treatment there was a significant effect of the IT treatment (A) (P <0.05), but not the i.p. treatment (B).Back to article page