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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice

Figure 8

IT IFNβ transiently reverses L5 SNL induced tactile allodynia. Twelve days following L5 SNL, C57BL/6 mice received IFNβ either (A) intrathecally or (B) intraperitoneally. (A) IT IFNβ (100 ng/5 μL) transiently reversed the tactile allodynia present at 12 days post-L5 SNL in C57BL/6 mice. (B) IFNβ i.p. (7,500 U/100 μL) did not affect the tactile allodynia present at 12 days post-L5 SNL in C57BL/6 mice. Data expressed as mean ± SEM (n = 3–4 mice/group) and analyzed via 2-way ANOVA. Following IFNβ treatment there was a significant effect of the IT treatment (A) (P <0.05), but not the i.p. treatment (B).

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