Figure 11

Quantitation of tau burden using PHF1 for the cortex of 3xTg mice. The tau burden was analyzed semiquantitatively on a scale of 0 to 4. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with PHF1 from the cortex. (C) Bar graph of tau semiquantitative analysis for the cortex of Tg control and pBri-vaccinated mice. On average there was a 75% reduction in the areas occupied by PHF1 immunoreactivity accounting for phosphorylated tau (***P = 0.0017 by an unpaired two-tailed t-test). Tg, transgenic.